4i4h: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4i4h|  PDB=4i4h  |  SCENE=  }}
+===Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir===
-The entry 4i4h is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
-Authors: Sevrioukova, I.F., Poulos, T.L.
+==About this Structure==
+[[4i4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I4H OCA].
-Description: Crystal structure of CYP3A4 ligated to pyridine-substituted desoxyritonavir
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Poulos, T L.]]
+[[Category: Sevrioukova, I F.]]
+[[Category: Cytochrome b5]]
+[[Category: Cytochrome p450]]
+[[Category: Cytochrome p450 reductase]]
+[[Category: Endoplasmic reticulum]]
+[[Category: Monooxygenase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]