4bh2: Difference between revisions

Revision as of 14:26, 24 April 2013

Crystal Structure of the Haemagglutinin from a Transmissible Mutant H5 Influenza VirusCrystal Structure of the Haemagglutinin from a Transmissible Mutant H5 Influenza Virus

FunctionFunction

[Q5EP31_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]

About this StructureAbout this Structure

4bh2 is a 2 chain structure with sequence from Influenza a virus (a/viet nam/1203/2004(h5n1)). Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
+{{STRUCTURE_4bh2|  PDB=4bh2  |  SCENE=  }}
+===Crystal Structure of the Haemagglutinin from a Transmissible Mutant H5 Influenza Virus===
-The entry 4bh2 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/Q5EP31_9INFA Q5EP31_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
-Authors: Xiong, X., Coombs, P., R Martin, S., Liu, J., Xiao, H., McCauley, J.W., Locher, K., Walker, P.A., Collins, P.J., Kawaoka, Y., Skehel, J.J., Gamblin, S.J.
+==About this Structure==
+[[4bh2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BH2 OCA].
-Description: Crystal Structure of the Haemagglutinin from a Transmissible Mutant H5 Influenza Virus
+[[Category: Collins, P J.]]
+[[Category: Coombs, P J.]]
+[[Category: Gamblin, S J.]]
+[[Category: Kawaoka, Y.]]
+[[Category: Liu, J.]]
+[[Category: Locher, K.]]
+[[Category: Martin, S R.]]
+[[Category: McCauley, J W.]]
+[[Category: Skehel, J J.]]
+[[Category: Walker, P A.]]
+[[Category: Xiao, H.]]
+[[Category: Xiong, X.]]
+[[Category: Bird flu]]
+[[Category: N-glycosylation]]
+[[Category: Viral protein]]
+[[Category: Virus receptor]]