3mqc: Difference between revisions

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-{{Seed}}
-[[Image:3mqc.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3mqc", creates the "Structure Box" on the page.
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-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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 {{STRUCTURE_3mqc|  PDB=3mqc  |  SCENE=  }}
 ===Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (P21)===
+{{ABSTRACT_PUBMED_20940320}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/BST2_HUMAN BST2_HUMAN]] IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.<ref>PMID:18342597</ref> <ref>PMID:18200009</ref> <ref>PMID:19879838</ref> <ref>PMID:19564354</ref> <ref>PMID:19036818</ref> <ref>PMID:19179289</ref> <ref>PMID:20686043</ref> <ref>PMID:20943977</ref> <ref>PMID:20419159</ref> <ref>PMID:21529378</ref> <ref>PMID:21621240</ref> <ref>PMID:22065321</ref> <ref>PMID:22520941</ref> <ref>PMID:20399176</ref> <ref>PMID:20940320</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_20940320}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 20940320 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20940320}}
 ==About this Structure==
-MQC is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQC OCA].
+[[3mqc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQC OCA].
 ==Reference==
-<ref group="xtra">PMID:20940320</ref><references group="xtra"/>
+<ref group="xtra">PMID:020940320</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Meng, W.]]
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 [[Category: Antiviral protein]]
 [[Category: Hiv]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 13:26:06 2010''