3n0e: Difference between revisions
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{{STRUCTURE_3n0e| PDB=3n0e | SCENE= }} | {{STRUCTURE_3n0e| PDB=3n0e | SCENE= }} | ||
===Crystal structure of WDR5 mutant (W330Y)=== | ===Crystal structure of WDR5 mutant (W330Y)=== | ||
{{ABSTRACT_PUBMED_20939513}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3n0e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0E OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020939513</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, R C.]] | [[Category: Chen, R C.]] | ||
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[[Category: Wd-repeat protein 5]] | [[Category: Wd-repeat protein 5]] | ||
[[Category: Wdr5]] | [[Category: Wdr5]] | ||