3n0e: Difference between revisions

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{{Seed}}
[[Image:3n0e.png|left|200px]]
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{{STRUCTURE_3n0e|  PDB=3n0e  |  SCENE=  }}  
{{STRUCTURE_3n0e|  PDB=3n0e  |  SCENE=  }}  
===Crystal structure of WDR5 mutant (W330Y)===
===Crystal structure of WDR5 mutant (W330Y)===
{{ABSTRACT_PUBMED_20939513}}


 
==Function==
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[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> 
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{{ABSTRACT_PUBMED_20939513}}


==About this Structure==
==About this Structure==
3N0E is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0E OCA].  
[[3n0e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0E OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20939513</ref><references group="xtra"/>
<ref group="xtra">PMID:020939513</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, R C.]]
[[Category: Chen, R C.]]
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[[Category: Wd-repeat protein 5]]
[[Category: Wd-repeat protein 5]]
[[Category: Wdr5]]
[[Category: Wdr5]]
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