4hfc: Difference between revisions
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' | {{STRUCTURE_4hfc| PDB=4hfc | SCENE= }} | ||
===The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanol=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | |||
==About this Structure== | |||
[[4hfc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFC OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Gloeobacter violaceus pcc 7421]] | |||
[[Category: Corringer, P J.]] | |||
[[Category: Delarue, M.]] | |||
[[Category: Harris, R A.]] | |||
[[Category: Howard, R J.]] | |||
[[Category: Lee, U S.]] | |||
[[Category: Malherbe, L.]] | |||
[[Category: Sauguet, L.]] | |||
[[Category: Ion-channel]] | |||
[[Category: Membrane protein]] | |||
[[Category: Pentameric transmembrane channel]] | |||
[[Category: Transport protein]] | |||
Revision as of 23:33, 17 April 2013
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanolThe GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanol
FunctionFunction
[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]
About this StructureAbout this Structure
4hfc is a 5 chain structure with sequence from Gloeobacter violaceus pcc 7421. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371