3maz: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3maz.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3maz", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3maz|  PDB=3maz  |  SCENE=  }}  
{{STRUCTURE_3maz|  PDB=3maz  |  SCENE=  }}  
===Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide===
===Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide===
{{ABSTRACT_PUBMED_20442417}}


==Disease==
[[http://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Williams syndrome. Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.<ref>PMID:11124535</ref> <ref>PMID:11003705</ref> <ref>PMID:11124535</ref> 


<!--
==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20442417}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/STAP1_HUMAN STAP1_HUMAN]] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<ref>PMID:10518561</ref>  [[http://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.<ref>PMID:12486104</ref> <ref>PMID:12514734</ref> <ref>PMID:15010370</ref> 
(as it appears on PubMed at http://www.pubmed.gov), where 20442417 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20442417}}


==About this Structure==
==About this Structure==
3MAZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA].  
[[3maz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20442417</ref><references group="xtra"/>
<ref group="xtra">PMID:020442417</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Huang, H.]]
[[Category: Huang, H.]]
Line 34: Line 24:
[[Category: Wu, C.]]
[[Category: Wu, C.]]
[[Category: Zhao, B.]]
[[Category: Zhao, B.]]
[[Category: Cytoplasm]]
[[Category: Modular domain]]
[[Category: Modular domain]]
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
Line 41: Line 30:
[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Specificity]]
[[Category: Specificity]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 11:02:51 2010''

Revision as of 02:24, 11 April 2013

Template:STRUCTURE 3maz

Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 PeptideCrystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide

Template:ABSTRACT PUBMED 20442417

DiseaseDisease

[NTAL_HUMAN] Williams syndrome. Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.[1] [2] [3]

FunctionFunction

[STAP1_HUMAN] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.[4] [NTAL_HUMAN] Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.[5] [6] [7]

About this StructureAbout this Structure

3maz is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Kaneko T, Huang H, Zhao B, Li L, Liu H, Voss CK, Wu C, Schiller MR, Li SS. Loops govern SH2 domain specificity by controlling access to binding pockets. Sci Signal. 2010 May 4;3(120):ra34. PMID:20442417 doi:3/120/ra34
  1. ↑ Doyle JL, DeSilva U, Miller W, Green ED. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet Cell Genet. 2000;90(3-4):285-90. PMID:11124535
  2. ↑ Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Mamm Genome. 2000 Oct;11(10):890-8. PMID:11003705
  3. ↑ Doyle JL, DeSilva U, Miller W, Green ED. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet Cell Genet. 2000;90(3-4):285-90. PMID:11124535
  4. ↑ Ohya K, Kajigaya S, Kitanaka A, Yoshida K, Miyazato A, Yamashita Y, Yamanaka T, Ikeda U, Shimada K, Ozawa K, Mano H. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11976-81. PMID:10518561
  5. ↑ Brdicka T, Imrich M, Angelisova P, Brdickova N, Horvath O, Spicka J, Hilgert I, Luskova P, Draber P, Novak P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsi V. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J Exp Med. 2002 Dec 16;196(12):1617-26. PMID:12486104
  6. ↑ Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W. LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol. 2003 Feb;4(2):117-23. Epub 2003 Jan 6. PMID:12514734 doi:10.1038/ni882
  7. ↑ Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Satterthwaite AB, Nahm DH, Metcalfe DD, Gilfillan AM. NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. Blood. 2004 Jul 1;104(1):207-14. Epub 2004 Mar 9. PMID:15010370 doi:10.1182/blood-2003-08-2769

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3maz&oldid=1774751"