3mcf: Difference between revisions
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{{STRUCTURE_3mcf| PDB=3mcf | SCENE= }} | {{STRUCTURE_3mcf| PDB=3mcf | SCENE= }} | ||
===Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha=== | ===Crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/NUD10_HUMAN NUD10_HUMAN]] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. | |||
==About this Structure== | ==About this Structure== | ||
[[3mcf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCF OCA]. | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||