4j31: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4j31|  PDB=4j31  |  SCENE=  }}
===Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot)===


The entry 4j31 is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.<ref>PMID:12062417</ref> <ref>PMID:15806102</ref>  


Authors: Amaral, M., Levy, C., Heyes, D.J., Lafite, P., Outeiro, T.F., Giorgini, F., Leys, D., Scrutton, N.S.
==About this Structure==
[[4j31]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J31 OCA].  


Description: Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot)
==Reference==
<references group="xtra"/><references/>
[[Category: Kynurenine 3-monooxygenase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Amaral, M.]]
[[Category: Giorgini, F.]]
[[Category: Heyes, D J.]]
[[Category: Lafite, P.]]
[[Category: Levy, C.]]
[[Category: Leys, D.]]
[[Category: Outeiro, T F.]]
[[Category: Scrutton, N S.]]
[[Category: Monooxygenase kynuramine]]
[[Category: Oxidoreductase]]

Revision as of 01:49, 11 April 2013

Template:STRUCTURE 4j31

Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot)Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot)

FunctionFunction

[KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.[1] [2]

About this StructureAbout this Structure

4j31 is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

  1. ↑ Panozzo C, Nawara M, Suski C, Kucharczyka R, Skoneczny M, Becam AM, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Lett. 2002 Apr 24;517(1-3):97-102. PMID:12062417
  2. ↑ Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat Genet. 2005 May;37(5):526-31. Epub 2005 Apr 3. PMID:15806102 doi:ng1542

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