4dom: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4dom|  PDB=4dom  |  SCENE=  }}
+===Crystal Structure of the TIR-domain of Human Myeloid Differentiation Primary Response protein (MyD88)===
-The entry 4dom is ON HOLD  until Aug 13 2014
+==Disease==
+[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[http://omim.org/entry/612260 612260]]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
-Authors: Jiang, J.S., Snyder, G.A., Xiao, T.
+==Function==
+[[http://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN]] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
-Description: Crystal Structure of the TIR-domain of Human Myeloid Differentiation Primary Response protein (MyD88)
+==About this Structure==
+[[4dom]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DOM OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Jiang, J S.]]
+[[Category: Snyder, G A.]]
+[[Category: Xiao, T.]]
+[[Category: Adopter domain]]
+[[Category: Innate immune signaling]]
+[[Category: Lysine methylation]]
+[[Category: Myd88_human]]
+[[Category: Signaling protein]]
+[[Category: Tir-domain]]
+[[Category: Tirap/mal]]
+[[Category: Toll-like receptor]]