3zon: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3zon|  PDB=3zon  |  SCENE=  }}
+===Human TYK2 pseudokinase domain bound to a kinase inhibitor===
-The entry 3zon is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Mendelian susceptibility to mycobacterial diseases;Autosomal recessive hyper IgE syndrome. Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:[http://omim.org/entry/611521 611521]]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
-Authors: Elkins, J.M., Wang, J., Krojer, T., Savitsky, P., Chalk, R., Daga, N., Salah, E., Berridge, G., Picaud, S., von Delft, F., Bountra, C., Edwards, A., Knapp, S.
+==Function==
+[[http://www.uniprot.org/uniprot/TYK2_HUMAN TYK2_HUMAN]] Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.<ref>PMID:7526154</ref>
-Description: Human TYK2 pseudokinase domain bound to a kinase inhibitor
+==About this Structure==
+[[3zon]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZON OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Berridge, G.]]
+[[Category: Bountra, C.]]
+[[Category: Chalk, R.]]
+[[Category: Daga, N.]]
+[[Category: Delft, F von.]]
+[[Category: Edwards, A.]]
+[[Category: Elkins, J M.]]
+[[Category: Knapp, S.]]
+[[Category: Krojer, T.]]
+[[Category: Picaud, S.]]
+[[Category: Salah, E.]]
+[[Category: Savitsky, P.]]
+[[Category: Wang, J.]]
+[[Category: Jak]]
+[[Category: Transferase]]