3ks8: Difference between revisions

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Revision as of 23:41, 4 April 2013

Template:STRUCTURE 3ks8

Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNACrystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA

Template:ABSTRACT PUBMED 20018665

FunctionFunction

[VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

About this StructureAbout this Structure

3ks8 is a 6 chain structure with sequence from Reston ebolavirus. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, Macrae IJ, Saphire EO. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A. 2009 Dec 14. PMID:20018665

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OCA
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