3ld6: Difference between revisions
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Revision as of 22:58, 4 April 2013
Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazoleCrystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole
Template:ABSTRACT PUBMED 20149798
FunctionFunction
[CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
About this StructureAbout this Structure
3ld6 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3i3k. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Sterol 14-demethylase
- Arrowsmith, C H.
- Bountra, C.
- Edwards, A M
- MacKenzie, F.
- Park, H.
- SGC, Structural Genomics Consortium.
- Strushkevich, N.
- Tempel, W.
- Weigelt, J.
- Cholesterol biosynthesis
- Cytochrome p450
- Endoplasmic reticulum
- Heme
- Iron
- Ketoconazole
- Lipid synthesis
- Membrane
- Metal-binding
- Microsome
- Monooxygenase
- Nadp
- Oxidoreductase
- Sgc
- Steroid biosynthesis
- Sterol 14alpha-demethylase
- Sterol biosynthesis
- Structural genomic
- Structural genomics consortium
- Transmembrane