Neurexin: Difference between revisions

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[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons.  The NRXN family contains 4 members which are numbered 1 to 4.  The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6.  
[[Neurexin|Neurexins]] (NRXN) are a family of presynaptic proteins which bind to the postsynaptic [[Neuroligin]] (NLGN) to form a complex which attaches neurons.  The NRXN family contains 4 members which are numbered 1 to 4.  The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See [[Neurodevelopmental Disorders]].


For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]]
For Structural Analysis of Neurexin, See: [[Neuroligin-Neurexin Interaction]]

Revision as of 12:20, 4 April 2013

File:3bod.png
Crystal Structure of mouse neurexin 1α LNS domain (3bod)

Template:STRUCTURE 3bod












Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See Neurodevelopmental Disorders.

For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction


3D Structures of Neurexin3D Structures of Neurexin

Updated February 2013

NRXNNRXN

3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
3bod, 3bop - mNRXN-1α LNS domain
3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
2r16 - rNRXN-1α LNS domain+Ca
1c4r - rNRXN-1α LNS domain
3mw4 - mNRXN-1α LNS domain
2h0b - bNRXN-1α LNS2 domain – bovine
3asi - bNRXN-1α LNS5-EGF3-LNS6 domains
3poy - bNRXN-1α LNS2-LNS6 domains (mutant)
3qcw, 3r05 - bNRXN-1α LNS1-LNS6 domains (mutant)
2r1d - rNRXN-1β LNS/LG domain

NRXN+NLGNNRXN+NLGN

2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain
3vkf - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, David Canner, Michal Harel, Joel L. Sussman
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