3kq0: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
m Protected "3kq0" [edit=sysop:move=sysop] |
(No difference)
| |
Revision as of 05:46, 4 April 2013
Crystal structure of human alpha1-acid glycoproteinCrystal structure of human alpha1-acid glycoprotein
Template:ABSTRACT PUBMED 18823996
FunctionFunction
[A1AG1_HUMAN] Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.[1] [2]
About this StructureAbout this Structure
3kq0 is a 1 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3bx6. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Schonfeld DL, Ravelli RB, Mueller U, Skerra A. The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin. J Mol Biol. 2008 Dec 12;384(2):393-405. Epub 2008 Sep 16. PMID:18823996 doi:10.1016/j.jmb.2008.09.020
- ↑ Fitos I, Visy J, Zsila F, Mady G, Simonyi M. Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein. Biochim Biophys Acta. 2006 Nov;1760(11):1704-12. Epub 2006 Aug 25. PMID:17008009 doi:10.1016/j.bbagen.2006.08.015
- ↑ Zsila F, Iwao Y. The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra. Biochim Biophys Acta. 2007 May;1770(5):797-809. Epub 2007 Jan 28. PMID:17321687 doi:10.1016/j.bbagen.2007.01.009