3kk9: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3kk9| PDB=3kk9 | SCENE= }} | {{STRUCTURE_3kk9| PDB=3kk9 | SCENE= }} | ||
===CaMKII Substrate Complex B=== | ===CaMKII Substrate Complex B=== | ||
{{ABSTRACT_PUBMED_20139983}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q9U6Q0_CAEEL Q9U6Q0_CAEEL]] Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:17898212</ref> <ref>PMID:17942636</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3kk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020139983</ref><references group="xtra"/><references/> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Barclay, L A.]] | [[Category: Barclay, L A.]] | ||
| Line 37: | Line 24: | ||
[[Category: Serine/threonine-protein kinase]] | [[Category: Serine/threonine-protein kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 05:43, 4 April 2013
CaMKII Substrate Complex BCaMKII Substrate Complex B
Template:ABSTRACT PUBMED 20139983
FunctionFunction
[Q9U6Q0_CAEEL] Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.[1] [2] [3] [4]
About this StructureAbout this Structure
3kk9 is a 1 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Chao LH, Pellicena P, Deindl S, Barclay LA, Schulman H, Kuriyan J. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat Struct Mol Biol. 2010 Mar;17(3):264-72. Epub 2010 Feb 7. PMID:20139983 doi:10.1038/nsmb.1751
- ↑ Solomon A, Bandhakavi S, Jabbar S, Shah R, Beitel GJ, Morimoto RI. Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Genetics. 2004 May;167(1):161-70. PMID:15166144
- ↑ Umemura T, Rapp P, Rongo C. The role of regulatory domain interactions in UNC-43 CaMKII localization and trafficking. J Cell Sci. 2005 Aug 1;118(Pt 15):3327-38. PMID:16079277 doi:10.1242/jcs.02457
- ↑ Liu Q, Chen B, Ge Q, Wang ZW. Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction. J Neurosci. 2007 Sep 26;27(39):10404-13. PMID:17898212 doi:10.1523/JNEUROSCI.5634-06.2007
- ↑ Nehrke K, Denton J, Mowrey W. Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program. Am J Physiol Cell Physiol. 2008 Jan;294(1):C333-44. Epub 2007 Oct 17. PMID:17942636 doi:10.1152/ajpcell.00303.2007