3k84: Difference between revisions
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{{STRUCTURE_3k84| PDB=3k84 | SCENE= }} | {{STRUCTURE_3k84| PDB=3k84 | SCENE= }} | ||
===Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase=== | ===Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase=== | ||
{{ABSTRACT_PUBMED_19924997}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3k84]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K84 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019924997</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Boger, D L.]] | [[Category: Boger, D L.]] | ||
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[[Category: Serine hydrolase]] | [[Category: Serine hydrolase]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||