3kl4: Difference between revisions
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{{STRUCTURE_3kl4| PDB=3kl4 | SCENE= }} | {{STRUCTURE_3kl4| PDB=3kl4 | SCENE= }} | ||
===Recognition of a signal peptide by the signal recognition particle=== | ===Recognition of a signal peptide by the signal recognition particle=== | ||
{{ABSTRACT_PUBMED_20364120}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SRP54_SULSO SRP54_SULSO]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3kl4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/ | [[3kl4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KL4 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020364120</ref><ref group="xtra">PMID:009695947</ref><ref group="xtra">PMID:014657338</ref><ref group="xtra">PMID:017086193</ref><references group="xtra"/><references/> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Signal-recognition-particle GTPase]] | [[Category: Signal-recognition-particle GTPase]] | ||
[[Category: Sulfolobus solfataricus | [[Category: Sulfolobus solfataricus]] | ||
[[Category: Janda, C Y.]] | [[Category: Janda, C Y.]] | ||
[[Category: Li, J.]] | [[Category: Li, J.]] | ||
Revision as of 05:15, 4 April 2013
Recognition of a signal peptide by the signal recognition particleRecognition of a signal peptide by the signal recognition particle
Template:ABSTRACT PUBMED 20364120
FunctionFunction
[SRP54_SULSO] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).
About this StructureAbout this Structure
3kl4 is a 2 chain structure with sequence from Saccharomyces cerevisiae and Sulfolobus solfataricus. Full crystallographic information is available from OCA.
ReferenceReference
[xtra 1][xtra 2][xtra 3][xtra 4]
- ↑ Janda CY, Li J, Oubridge C, Hernandez H, Robinson CV, Nagai K. Recognition of a signal peptide by the signal recognition particle. Nature. 2010 May 27;465(7297):507-10. Epub 2010 Apr 4. PMID:20364120 doi:10.1038/nature08870
- ↑ Keenan RJ, Freymann DM, Walter P, Stroud RM. Crystal structure of the signal sequence binding subunit of the signal recognition particle. Cell. 1998 Jul 24;94(2):181-91. PMID:9695947
- ↑ Rosendal KR, Wild K, Montoya G, Sinning I. Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14701-6. Epub 2003 Dec 1. PMID:14657338 doi:10.1073/pnas.2436132100
- ↑ Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R. Following the signal sequence from ribosomal tunnel exit to signal recognition particle. Nature. 2006 Nov 23;444(7118):507-11. Epub 2006 Oct 29. PMID:17086193 doi:http://dx.doi.org/10.1038/nature05326