3krx: Difference between revisions
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{{STRUCTURE_3krx| PDB=3krx | SCENE= }} | {{STRUCTURE_3krx| PDB=3krx | SCENE= }} | ||
===Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)=== | ===Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)=== | ||
{{ABSTRACT_PUBMED_20128603}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARBK1_HUMAN ARBK1_HUMAN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.<ref>PMID:19306925</ref> [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | |||
(as | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020128603</ref><references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Tesmer, J J.G.]] | [[Category: Tesmer, J J.G.]] | ||
[[Category: Tesmer, V M.]] | [[Category: Tesmer, V M.]] | ||
[[Category: Atp-binding]] | |||
[[Category: Cell membrane]] | |||
[[Category: Lipoprotein]] | |||
[[Category: Membrane]] | |||
[[Category: Methylation]] | |||
[[Category: Phosphoprotein]] | |||
[[Category: Prenylation]] | |||
[[Category: Protein binding]] | |||
[[Category: Rgs homology domain]] | |||
[[Category: Serine/threonine-protein kinase]] | |||
[[Category: Transducer]] | |||
[[Category: Transferase]] | |||
[[Category: Wd repeat]] |