3kku: Difference between revisions
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Revision as of 05:09, 4 April 2013
Cruzain in complex with a non-covalent ligandCruzain in complex with a non-covalent ligand
Template:ABSTRACT PUBMED 20540517
FunctionFunction
[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
About this StructureAbout this Structure
3kku is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905. PMID:20540517 doi:10.1021/jm100488w