4ibx: Difference between revisions

Revision as of 04:49, 4 April 2013

Crystal structure of stabilized TEM-1 beta-lactamase variant v.13Crystal structure of stabilized TEM-1 beta-lactamase variant v.13

FunctionFunction

[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

About this StructureAbout this Structure

4ibx is a 5 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
+{{STRUCTURE_4ibx|  PDB=4ibx  |  SCENE=  }}
+===Crystal structure of stabilized TEM-1 beta-lactamase variant v.13===
-The entry 4ibx is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
-Authors: Dellus-Gur, E., Toth-Petroczy, A., Elias, M., Tawfik, D.S.
+==About this Structure==
+[[4ibx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IBX OCA].
-Description: Crystal structure of stabilized TEM-1 beta-lactamase variant v.13
+[[Category: Beta-lactamase]]
+[[Category: Escherichia coli]]
+[[Category: Dellus-Gur, E.]]
+[[Category: Elias, M.]]
+[[Category: Tawfik, D S.]]
+[[Category: Toth-Petroczy, A.]]
+[[Category: Hydrolase]]
+[[Category: Tem-1 beta-lactamase]]