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{{STRUCTURE_2ymk| PDB=2ymk | SCENE= }} | {{STRUCTURE_2ymk| PDB=2ymk | SCENE= }} | ||
===Crystal structure of the hexameric anti-microbial peptide channel dermcidin=== | ===Crystal structure of the hexameric anti-microbial peptide channel dermcidin=== | ||
{{ABSTRACT_PUBMED_23426625}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DCD_HUMAN DCD_HUMAN]] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.<ref>PMID:17448443</ref> Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.<ref>PMID:17448443</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2ymk]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMK OCA]. | [[2ymk]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YMK OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Zeth, K.]] | [[Category: Zeth, K.]] | ||
[[Category: Anti-microbial peptide channel]] | [[Category: Anti-microbial peptide channel]] | ||
Revision as of 03:21, 4 April 2013
Crystal structure of the hexameric anti-microbial peptide channel dermcidinCrystal structure of the hexameric anti-microbial peptide channel dermcidin
Template:ABSTRACT PUBMED 23426625
FunctionFunction
[DCD_HUMAN] DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.[1] Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.[2]
About this StructureAbout this Structure
2ymk is a 3 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Lee Motoyama JP, Kim-Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem Biophys Res Commun. 2007 Jun 15;357(4):828-33. Epub 2007 Mar 28. PMID:17448443 doi:10.1016/j.bbrc.2007.03.112
- ↑ Lee Motoyama JP, Kim-Motoyama H, Kim P, Nakagama H, Miyagawa K, Suzuki K. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. Biochem Biophys Res Commun. 2007 Jun 15;357(4):828-33. Epub 2007 Mar 28. PMID:17448443 doi:10.1016/j.bbrc.2007.03.112