4ie2: Difference between revisions

Revision as of 01:09, 4 April 2013

Crystal structure of human Arginase-2 complexed with inhibitor 1hCrystal structure of human Arginase-2 complexed with inhibitor 1h

FunctionFunction

[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

About this StructureAbout this Structure

4ie2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
+{{STRUCTURE_4ie2|  PDB=4ie2  |  SCENE=  }}
+===Crystal structure of human Arginase-2 complexed with inhibitor 1h===
+{{ABSTRACT_PUBMED_23453840}}
-The entry 4ie2 is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
-Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Beckett ,P., Van Zandt, M.C., Ji, M.K., Whitehouse, D., Ryder, T., Jagdmann, E., Andreoli, M., Mazur, A., Padmanilayam, M., Schroeter, H., Golebiowski, A., Podjarny, A.
+==About this Structure==
+[[4ie2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IE2 OCA].
-Description: Crystal structure of human Arginase-2 complexed with inhibitor 1h
+[[Category: Arginase]]
+[[Category: Homo sapiens]]
+[[Category: Andreoli, M.]]
+[[Category: Beckett ,P.]]
+[[Category: Cousido-Siah, A.]]
+[[Category: Golebiowski, A.]]
+[[Category: Jagdmann, E.]]
+[[Category: Ji, M K.]]
+[[Category: Mazur, A.]]
+[[Category: Mitschler, A.]]
+[[Category: Padmanilayam, M.]]
+[[Category: Podjarny, A.]]
+[[Category: Ruiz, F X.]]
+[[Category: Ryder, T.]]
+[[Category: Schroeter, H.]]
+[[Category: Whitehouse, D.]]
+[[Category: Zandt, M C.Van.]]
+[[Category: Alpha/beta fold]]
+[[Category: Arginine metabolism]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Manganese]]
+[[Category: Metalloenzyme]]
+[[Category: Mitochondrion]]