Human growth hormone: Difference between revisions
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==Post-translational modifications== | ==Post-translational modifications== | ||
'''Phosphorylation'''<br/> | |||
HGH is phosphorylated on Ser residues 132 and 176 (Giorgianni, Beranova-Giorgianni, and Desiderio, 2004). Other research has indicated possible phosphorylation of Tyr residues 35 and 42. However, these phosphorylations were only investigated in carcinoma cells with constitutively active epidermal growth factor-stimulated tyrosine kinase (Baldwin et al., 1983). The overall influence of these post-translational modifications on hGH activity has yet to be determined. | HGH is phosphorylated on Ser residues 132 and 176 (Giorgianni, Beranova-Giorgianni, and Desiderio, 2004). Other research has indicated possible phosphorylation of Tyr residues 35 and 42. However, these phosphorylations were only investigated in carcinoma cells with constitutively active epidermal growth factor-stimulated tyrosine kinase (Baldwin et al., 1983). The overall influence of these post-translational modifications on hGH activity has yet to be determined. | ||