3hsm: Difference between revisions
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{{STRUCTURE_3hsm| PDB=3hsm | SCENE= }} | {{STRUCTURE_3hsm| PDB=3hsm | SCENE= }} | ||
===Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1=== | ===Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1=== | ||
{{ABSTRACT_PUBMED_19541610}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref><ref>PMID:22036948</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019541610</ref><references group="xtra"/> | <ref group="xtra">PMID:019541610</ref><references group="xtra"/><references/> | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Amador, F J.]] | [[Category: Amador, F J.]] | ||
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[[Category: Wilson, A.]] | [[Category: Wilson, A.]] | ||
[[Category: Beta-trefoil]] | [[Category: Beta-trefoil]] | ||
[[Category: Calcium channel]] | [[Category: Calcium channel]] | ||
[[Category: Calcium transport]] | [[Category: Calcium transport]] |