3jqb: Difference between revisions
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{{STRUCTURE_3jqb| PDB=3jqb | SCENE= }} | {{STRUCTURE_3jqb| PDB=3jqb | SCENE= }} | ||
===Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6)=== | ===Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6)=== | ||
{{ABSTRACT_PUBMED_19916554}} | {{ABSTRACT_PUBMED_19916554}} | ||
==About this Structure== | ==About this Structure== | ||
[[3jqb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bmh 3bmh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQB OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:019916554</ref><references group="xtra"/><references/> | ||
[[Category: Pteridine reductase]] | [[Category: Pteridine reductase]] | ||
[[Category: Trypanosoma brucei]] | [[Category: Trypanosoma brucei]] | ||
| Line 34: | Line 18: | ||
[[Category: Short chain dehydrogenase]] | [[Category: Short chain dehydrogenase]] | ||
[[Category: Trypanosoma brucei]] | [[Category: Trypanosoma brucei]] | ||
Revision as of 12:24, 27 March 2013
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6)Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6)
Template:ABSTRACT PUBMED 19916554
About this StructureAbout this Structure
3jqb is a 4 chain structure with sequence from Trypanosoma brucei. This structure supersedes the now removed PDB entry 3bmh. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Tulloch LB, Martini VP, Iulek J, Huggan JK, Lee JH, Gibson CL, Smith TK, Suckling CJ, Hunter WN. Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases. J Med Chem. 2009 Nov 16. PMID:19916554 doi:10.1021/jm901059x