3jr3: Difference between revisions
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{{STRUCTURE_3jr3| PDB=3jr3 | SCENE= }} | {{STRUCTURE_3jr3| PDB=3jr3 | SCENE= }} | ||
===Sir2 bound to acetylated peptide=== | ===Sir2 bound to acetylated peptide=== | ||
{{ABSTRACT_PUBMED_019801667}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NPD_THEMA NPD_THEMA]] NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Has also depropionylation activity in vitro. Also able to ADP-ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear.<ref>PMID:17684016</ref><ref>PMID:16905097</ref><ref>PMID:19801667</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3jr3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JR3 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:019801667</ref><references group="xtra"/><references/> | |||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
[[Category: Hawse, W F.]] | [[Category: Hawse, W F.]] | ||
[[Category: Wolberger, C.]] | [[Category: Wolberger, C.]] | ||
[[Category: Deacetylation]] | [[Category: Deacetylation]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
| Line 26: | Line 21: | ||
[[Category: Ribosylation]] | [[Category: Ribosylation]] | ||
[[Category: Sir2]] | [[Category: Sir2]] | ||
Revision as of 12:20, 27 March 2013
Sir2 bound to acetylated peptideSir2 bound to acetylated peptide
Template:ABSTRACT PUBMED 019801667
FunctionFunction
[NPD_THEMA] NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Has also depropionylation activity in vitro. Also able to ADP-ribosylate peptide substrates with Arg or Lys in the +2 position. The role of this function in vivo is not clear.[1][2][3]
About this StructureAbout this Structure
3jr3 is a 2 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Hawse WF, Wolberger C. Structure-based mechanism of ADP-ribosylation by sirtuins. J Biol Chem. 2009 Nov 27;284(48):33654-61. Epub 2009 Sep 30. PMID:19801667 doi:10.1074/jbc.M109.024521
- ↑ Garrity J, Gardner JG, Hawse W, Wolberger C, Escalante-Semerena JC. N-lysine propionylation controls the activity of propionyl-CoA synthetase. J Biol Chem. 2007 Oct 12;282(41):30239-45. Epub 2007 Aug 7. PMID:17684016 doi:10.1074/jbc.M704409200
- ↑ Hoff KG, Avalos JL, Sens K, Wolberger C. Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure. 2006 Aug;14(8):1231-40. PMID:16905097 doi:http://dx.doi.org/10.1016/j.str.2006.06.006
- ↑ Hawse WF, Wolberger C. Structure-based mechanism of ADP-ribosylation by sirtuins. J Biol Chem. 2009 Nov 27;284(48):33654-61. Epub 2009 Sep 30. PMID:19801667 doi:10.1074/jbc.M109.024521