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===Refined NMR solution structure of the C-terminal UBA domain of the human homologue of RAD23A (HHR23A)=== | ===Refined NMR solution structure of the C-terminal UBA domain of the human homologue of RAD23A (HHR23A)=== | ||
{{ABSTRACT_PUBMED_11087358}} | {{ABSTRACT_PUBMED_11087358}} | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/RD23A_HUMAN RD23A_HUMAN]] Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.<ref>PMID:9372924</ref><ref>PMID:14621999</ref><ref>PMID:12643283</ref><ref>PMID:15321727</ref><ref>PMID:20614012</ref> Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.<ref>PMID:9372924</ref><ref>PMID:14621999</ref><ref>PMID:12643283</ref><ref>PMID:15321727</ref><ref>PMID:20614012</ref> Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.<ref>PMID:9372924</ref><ref>PMID:14621999</ref><ref>PMID:12643283</ref><ref>PMID:15321727</ref><ref>PMID:20614012</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011087358</ref><references group="xtra"/> | <ref group="xtra">PMID:011087358</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, I S.]] | [[Category: Chen, I S.]] | ||