2xn3: Difference between revisions
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{{STRUCTURE_2xn3| PDB=2xn3 | SCENE= }} | {{STRUCTURE_2xn3| PDB=2xn3 | SCENE= }} | ||
===CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH MEFENAMIC ACID=== | |||
{{ABSTRACT_PUBMED_21325280}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:[http://omim.org/entry/314200 314200]]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/THBG_HUMAN THBG_HUMAN]] Major thyroid hormone transport protein in serum. | |||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 17: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021325280</ref><references group="xtra"/> | <ref group="xtra">PMID:021325280</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Qi, X.]] | [[Category: Qi, X.]] | ||
Revision as of 10:18, 25 March 2013
CRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH MEFENAMIC ACIDCRYSTAL STRUCTURE OF THYROXINE-BINDING GLOBULIN COMPLEXED WITH MEFENAMIC ACID
Template:ABSTRACT PUBMED 21325280
DiseaseDisease
[THBG_HUMAN] Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.
FunctionFunction
[THBG_HUMAN] Major thyroid hormone transport protein in serum.
About this StructureAbout this Structure
2xn3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A. Allosteric modulation of hormone release from thyroxine and corticosteroid binding-globulins. J Biol Chem. 2011 Feb 16. PMID:21325280 doi:10.1074/jbc.M110.171082