2wy3: Difference between revisions
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{{STRUCTURE_2wy3| PDB=2wy3 | SCENE= }} | {{STRUCTURE_2wy3| PDB=2wy3 | SCENE= }} | ||
===STRUCTURE OF THE HCMV UL16-MICB COMPLEX ELUCIDATES SELECT BINDING OF A VIRAL IMMUNOEVASIN TO DIVERSE NKG2D LIGANDS=== | ===STRUCTURE OF THE HCMV UL16-MICB COMPLEX ELUCIDATES SELECT BINDING OF A VIRAL IMMUNOEVASIN TO DIVERSE NKG2D LIGANDS=== | ||
{{ABSTRACT_PUBMED_20090832}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UL16P_HCMVA UL16P_HCMVA]] Plays a role in escape from host immune response. Blocks the interaction between the host NKG2D receptor with the ligands ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. The sequestration of diverse NKG2D ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells.<ref>PMID:12847260</ref><ref>PMID:12782710</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020090832</ref><references group="xtra"/> | <ref group="xtra">PMID:020090832</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human herpesvirus 5 strain ad169]] | [[Category: Human herpesvirus 5 strain ad169]] | ||
Revision as of 10:08, 25 March 2013
STRUCTURE OF THE HCMV UL16-MICB COMPLEX ELUCIDATES SELECT BINDING OF A VIRAL IMMUNOEVASIN TO DIVERSE NKG2D LIGANDSSTRUCTURE OF THE HCMV UL16-MICB COMPLEX ELUCIDATES SELECT BINDING OF A VIRAL IMMUNOEVASIN TO DIVERSE NKG2D LIGANDS
Template:ABSTRACT PUBMED 20090832
FunctionFunction
[UL16P_HCMVA] Plays a role in escape from host immune response. Blocks the interaction between the host NKG2D receptor with the ligands ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. The sequestration of diverse NKG2D ligands in the endoplasmic reticulum and cis-Golgi apparatus of cells by UL16 inhibits the activation of NK cells.[1][2]
About this StructureAbout this Structure
2wy3 is a 4 chain structure with sequence from Homo sapiens and Human herpesvirus 5 strain ad169. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Muller S, Zocher G, Steinle A, Stehle T. Structure of the HCMV UL16-MICB complex elucidates select binding of a viral immunoevasin to diverse NKG2D ligands. PLoS Pathog. 2010 Jan 15;6(1):e1000723. PMID:20090832 doi:10.1371/journal.ppat.1000723
- ↑ Rolle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Soderberg-Naucler C, Cosman D, Karre K, Cerboni C. Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein. J Immunol. 2003 Jul 15;171(2):902-8. PMID:12847260
- ↑ Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J Exp Med. 2003 Jun 2;197(11):1427-39. PMID:12782710 doi:10.1084/jem.20022059
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OCACategories:
- Homo sapiens
- Human herpesvirus 5 strain ad169
- Mueller, S.
- Stehle, T.
- Steinle, A.
- Zocher, G.
- Cell membrane
- Convergent evolution
- Cytolysis
- Immune response
- Immune system-viral protein complex
- Immunoglobulin domain
- Innate immunity
- Membrane
- Natural killer cell
- Nk cell
- Nkg2d
- Structural mimicry
- Transmembrane
- Ulbp
- Viral immune evasion