3d4n: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:3d4n.png|left|200px]]
 {{STRUCTURE_3d4n|  PDB=3d4n  |  SCENE=  }}
+===Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor===
+{{ABSTRACT_PUBMED_18553955}}
-===Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide Inhibitor===
+==Disease==
+[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[http://omim.org/entry/604931 604931]]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
-{{ABSTRACT_PUBMED_18553955}}
+==Function==
+[[http://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:018553955</ref><references group="xtra"/>
+<ref group="xtra">PMID:018553955</ref><references group="xtra"/><references/>
 [[Category: 11-beta-hydroxysteroid dehydrogenase]]
 [[Category: Homo sapiens]]