3uv5: Difference between revisions

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-[[Image:3uv5.png|left|200px]]
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 {{STRUCTURE_3uv5|  PDB=3uv5  |  SCENE=  }}
 ===Crystal Structure of the tandem bromodomains of human Transcription initiation factor TFIID subunit 1 (TAF1)===
+{{ABSTRACT_PUBMED_22464331}}
+==Disease==
+[[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:[http://omim.org/entry/314250 314250]]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.<ref>PMID:12928496</ref><ref>PMID:17273961</ref>
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+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.<ref>PMID:2038334</ref><ref>PMID:8450888</ref><ref>PMID:8625415</ref><ref>PMID:9660973</ref><ref>PMID:9858607</ref><ref>PMID:11278496</ref><ref>PMID:15053879</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 22464331 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_22464331}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:022464331</ref><references group="xtra"/>
+<ref group="xtra">PMID:022464331</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Non-specific serine/threonine protein kinase]]