3lp7: Difference between revisions
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{{STRUCTURE_3lp7| PDB=3lp7 | SCENE= }} | {{STRUCTURE_3lp7| PDB=3lp7 | SCENE= }} | ||
===Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution=== | ===Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution=== | ||
{{ABSTRACT_PUBMED_20153713}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref><ref>PMID:7649538</ref> | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020153713</ref><references group="xtra"/><references/> | ||
[[Category: Arginase]] | [[Category: Arginase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Christianson, D W.]] | [[Category: Christianson, D W.]] | ||
[[Category: Costanzo, L Di.]] | [[Category: Costanzo, L Di.]] | ||
[[Category: Arginine metabolism]] | [[Category: Arginine metabolism]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
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[[Category: Noha inhibition]] | [[Category: Noha inhibition]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Urea cycle]] | [[Category: Urea cycle]] | ||