1pu5: Difference between revisions
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{{STRUCTURE_1pu5| PDB=1pu5 | SCENE= }} | {{STRUCTURE_1pu5| PDB=1pu5 | SCENE= }} | ||
===GM2-activator Protein crystal structure=== | |||
{{ABSTRACT_PUBMED_12909021}} | |||
===GM2- | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SAP3_HUMAN SAP3_HUMAN]] Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:[http://omim.org/entry/272750 272750]]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.<ref>PMID:1915858</ref><ref>PMID:8244332</ref><ref>PMID:8900233</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SAP3_HUMAN SAP3_HUMAN]] The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012909021</ref><references group="xtra"/> | <ref group="xtra">PMID:012909021</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Rastinejad, F.]] | [[Category: Rastinejad, F.]] | ||