1wm0: Difference between revisions
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{{STRUCTURE_1wm0| PDB=1wm0 | SCENE= }} | {{STRUCTURE_1wm0| PDB=1wm0 | SCENE= }} | ||
===PPARgamma in complex with a 2-BABA compound=== | ===PPARgamma in complex with a 2-BABA compound=== | ||
{{ABSTRACT_PUBMED_15258145}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/NCOA2_MOUSE NCOA2_MOUSE]] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:12507421</ref><ref>PMID:11997499</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:015258145</ref><references group="xtra"/> | <ref group="xtra">PMID:015258145</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gustavsson, A L.]] | [[Category: Gustavsson, A L.]] | ||
Revision as of 07:40, 25 March 2013
PPARgamma in complex with a 2-BABA compoundPPARgamma in complex with a 2-BABA compound
Template:ABSTRACT PUBMED 15258145
FunctionFunction
[NCOA2_MOUSE] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.[1][2]
About this StructureAbout this Structure
1wm0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Ostberg T, Svensson S, Selen G, Uppenberg J, Thor M, Sundbom M, Sydow-Backman M, Gustavsson AL, Jendeberg L. A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. J Biol Chem. 2004 Sep 24;279(39):41124-30. Epub 2004 Jul 15. PMID:15258145 doi:10.1074/jbc.M401552200
- ↑ Picard F, Gehin M, Annicotte J, Rocchi S, Champy MF, O'Malley BW, Chambon P, Auwerx J. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell. 2002 Dec 27;111(7):931-41. PMID:12507421
- ↑ Lee YH, Koh SS, Zhang X, Cheng X, Stallcup MR. Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol. 2002 Jun;22(11):3621-32. PMID:11997499