3o8e: Difference between revisions

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 {{STRUCTURE_3o8e|  PDB=3o8e  |  SCENE=  }}
 ===Structure of extracelllar portion of CD46 in complex with Adenovirus type 11 knob===
+{{ABSTRACT_PUBMED_20941397}}
+==Disease==
+[[http://www.uniprot.org/uniprot/MCP_HUMAN MCP_HUMAN]] Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2) [MIM:[http://omim.org/entry/612922 612922]]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations.<ref>PMID:14615110</ref><ref>PMID:14566051</ref><ref>PMID:16621965</ref><ref>PMID:16386793</ref><ref>PMID:20513133</ref>
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+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_20941397}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/MCP_HUMAN MCP_HUMAN]] Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.<ref>PMID:10843656</ref><ref>PMID:12540904</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 20941397 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_20941397}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:020941397</ref><references group="xtra"/>
+<ref group="xtra">PMID:020941397</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Human adenovirus 11]]