1cdr: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1cdr.png|left|200px]]
 {{STRUCTURE_1cdr|  PDB=1cdr  |  SCENE=  }}
+===STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59===
+{{ABSTRACT_PUBMED_7520819}}
-===STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59===
+==Disease==
+[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
-{{ABSTRACT_PUBMED_7520819}}
+==Function==
+[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.  The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:007520819</ref><references group="xtra"/>
+<ref group="xtra">PMID:007520819</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Fletcher, C M.]]