1pue: Difference between revisions
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{{STRUCTURE_1pue| PDB=1pue | SCENE= }} | {{STRUCTURE_1pue| PDB=1pue | SCENE= }} | ||
===PU.1 ETS DOMAIN-DNA COMPLEX=== | |||
{{ABSTRACT_PUBMED_8602247}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE]] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE]] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.<ref>PMID:8626664</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:008602247</ref><ref group="xtra">PMID:011258480</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/> | <ref group="xtra">PMID:008602247</ref><ref group="xtra">PMID:011258480</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/><references/> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Ely, K. R.]] | [[Category: Ely, K. R.]] | ||
Revision as of 07:15, 25 March 2013
PU.1 ETS DOMAIN-DNA COMPLEXPU.1 ETS DOMAIN-DNA COMPLEX
Template:ABSTRACT PUBMED 8602247
DiseaseDisease
[SPI1_MOUSE] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.
FunctionFunction
[SPI1_MOUSE] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.[1]
About this StructureAbout this Structure
1pue is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Kodandapani R, Pio F, Ni CZ, Piccialli G, Klemsz M, McKercher S, Maki RA, Ely KR. A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature. 1996 Apr 4;380(6573):456-60. PMID:8602247 doi:http://dx.doi.org/10.1038/380456a0
- ↑ Cokol M, Nair R, Rost B. Finding nuclear localization signals. EMBO Rep. 2000 Nov;1(5):411-5. PMID:11258480 doi:10.1093/embo-reports/kvd092
- ↑ Hicks JM, Hsu VL. The extended left-handed helix: a simple nucleic acid-binding motif. Proteins. 2004 May 1;55(2):330-8. PMID:15048824 doi:10.1002/prot.10630