1w70: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1w70.png|left|200px]]
 {{STRUCTURE_1w70|  PDB=1w70  |  SCENE=  }}
+===SH3 DOMAIN OF P40PHOX COMPLEXED WITH C-TERMINAL POLYPROLINE REGION OF P47PHOX===
+{{ABSTRACT_PUBMED_15657040}}
-===SH3 DOMAIN OF P40PHOX COMPLEXED WITH C-TERMINAL POLYPROLINE REGION OF P47PHOX===
+==Disease==
+[[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:[http://omim.org/entry/233700 233700]]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.<ref>PMID:2011585</ref><ref>PMID:11133775</ref>
-{{ABSTRACT_PUBMED_15657040}}
+==Function==
+[[http://www.uniprot.org/uniprot/NCF1_HUMAN NCF1_HUMAN]] NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).<ref>PMID:19801500</ref>
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:015657040</ref><references group="xtra"/>
+<ref group="xtra">PMID:015657040</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Brandolin, G.]]