3u3c: Difference between revisions
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{{STRUCTURE_3u3c| PDB=3u3c | SCENE= }} | {{STRUCTURE_3u3c| PDB=3u3c | SCENE= }} | ||
===Structural Basis for the interaction of Pyk2 PAT domain with paxillin LD motifs=== | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FAK2_HUMAN FAK2_HUMAN]] Note=Aberrant PTK2B/PYK2 expression may play a role in cancer cell proliferation, migration and invasion, in tumor formation and metastasis. Elevated PTK2B/PYK2 expression is seen in gliomas, hepatocellular carcinoma, lung cancer and breast cancer.<ref>PMID:18339875</ref><ref>PMID:18765415</ref><ref>PMID:19648005</ref><ref>PMID:21533080</ref><ref>PMID:20001213</ref><ref>PMID:19428251</ref><ref>PMID:19244237</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FAK2_HUMAN FAK2_HUMAN]] Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2.<ref>PMID:7544443</ref><ref>PMID:8849729</ref><ref>PMID:8670418</ref><ref>PMID:10022920</ref><ref>PMID:12771146</ref><ref>PMID:12893833</ref><ref>PMID:14585963</ref><ref>PMID:15050747</ref><ref>PMID:15166227</ref><ref>PMID:17634955</ref><ref>PMID:18339875</ref><ref>PMID:18765415</ref><ref>PMID:18086875</ref><ref>PMID:18587400</ref><ref>PMID:19207108</ref><ref>PMID:19648005</ref><ref>PMID:19086031</ref><ref>PMID:20521079</ref><ref>PMID:19880522</ref><ref>PMID:20381867</ref><ref>PMID:21357692</ref><ref>PMID:21533080</ref><ref>PMID:20001213</ref><ref>PMID:19428251</ref><ref>PMID:19244237</ref> [[http://www.uniprot.org/uniprot/PAXI_HUMAN PAXI_HUMAN]] Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). | |||
==About this Structure== | ==About this Structure== | ||
[[3u3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3C OCA]. | [[3u3c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3C OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||