2efl: Difference between revisions

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OCA

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-[[Image:2efl.png|left|200px]]
 {{STRUCTURE_2efl|  PDB=2efl  |  SCENE=  }}
+===Crystal structure of the EFC domain of formin-binding protein 17===
+{{ABSTRACT_PUBMED_17512409}}
-===Crystal structure of the EFC domain of formin-binding protein 17===
+==Disease==
+[[http://www.uniprot.org/uniprot/FNBP1_HUMAN FNBP1_HUMAN]] Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.
-{{ABSTRACT_PUBMED_17512409}}
+==Function==
+[[http://www.uniprot.org/uniprot/FNBP1_HUMAN FNBP1_HUMAN]] May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.<ref>PMID:15252009</ref><ref>PMID:16326391</ref><ref>PMID:16318909</ref><ref>PMID:16418535</ref><ref>PMID:17512409</ref>
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:017512409</ref><references group="xtra"/>
+<ref group="xtra">PMID:017512409</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Niwa, H.]]