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===Crystal structure of human autocrine motility factor complexed with an inhibitor=== | ===Crystal structure of human autocrine motility factor complexed with an inhibitor=== | ||
{{ABSTRACT_PUBMED_12054796}} | {{ABSTRACT_PUBMED_12054796}} | ||
==Disease== | |||
[[http://www.uniprot.org/uniprot/G6PI_HUMAN G6PI_HUMAN]] Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:[http://omim.org/entry/613470 613470]]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/G6PI_HUMAN G6PI_HUMAN]] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.<ref>PMID:11004567</ref><ref>PMID:11437381</ref><ref>PMID:12163179</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012054796</ref><references group="xtra"/> | <ref group="xtra">PMID:012054796</ref><references group="xtra"/><references/> | ||
[[Category: Glucose-6-phosphate isomerase]] | [[Category: Glucose-6-phosphate isomerase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||