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{{STRUCTURE_2ofs| PDB=2ofs | SCENE= }} | {{STRUCTURE_2ofs| PDB=2ofs | SCENE= }} | ||
===Crystal structure of human CD59=== | |||
{{ABSTRACT_PUBMED_17505110}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017505110</ref><references group="xtra"/> | <ref group="xtra">PMID:017505110</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Davies, C.]] | [[Category: Davies, C.]] | ||
[[Category: Complement inhibitor]] | [[Category: Complement inhibitor]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||