3teq: Difference between revisions

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-[[Image:3teq.jpg|left|200px]]
-<!--
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 {{STRUCTURE_3teq|  PDB=3teq  |  SCENE=  }}
 ===Crystal structure of SOAR domain===
+{{ABSTRACT_PUBMED_22451904}}
+==Disease==
+[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:[http://omim.org/entry/612783 612783]]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.<ref>PMID:19420366</ref>
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+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_22451904}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/STIM1_HUMAN STIM1_HUMAN]] Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.<ref>PMID:9377559</ref><ref>PMID:16005298</ref><ref>PMID:15866891</ref><ref>PMID:16208375</ref><ref>PMID:16807233</ref><ref>PMID:16766533</ref><ref>PMID:16733527</ref><ref>PMID:16537481</ref><ref>PMID:22464749</ref>
-(as it appears on PubMed at http://www.pubmed.gov), where 22451904 is the PubMed ID number.
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-{{ABSTRACT_PUBMED_22451904}}
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:022451904</ref><references group="xtra"/>
+<ref group="xtra">PMID:022451904</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cai, X.]]