1ap6: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:1ap6.png|left|200px]]
 {{STRUCTURE_1ap6|  PDB=1ap6  |  SCENE=  }}
+===TYR34->PHE MUTANT OF HUMAN MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE===
+{{ABSTRACT_PUBMED_9537987}}
-===TYR34->PHE MUTANT OF HUMAN MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE===
+==Disease==
+[[http://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN]] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:[http://omim.org/entry/612634 612634]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
-{{ABSTRACT_PUBMED_9537987}}
+==Function==
+[[http://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.<ref>PMID:10334867</ref>
 ==About this Structure==
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 ==Reference==
-<ref group="xtra">PMID:009537987</ref><references group="xtra"/>
+<ref group="xtra">PMID:009537987</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Superoxide dismutase]]