1g1r: Difference between revisions
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{{STRUCTURE_1g1r| PDB=1g1r | SCENE= }} | {{STRUCTURE_1g1r| PDB=1g1r | SCENE= }} | ||
===Crystal structure of P-selectin lectin/EGF domains complexed with SLeX=== | |||
{{ABSTRACT_PUBMED_11081633}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/LYAM3_HUMAN LYAM3_HUMAN]] Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:14681304</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LYAM3_HUMAN LYAM3_HUMAN]] Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.<ref>PMID:7585950</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011081633</ref><references group="xtra"/> | <ref group="xtra">PMID:011081633</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Camphausen, R T.]] | [[Category: Camphausen, R T.]] | ||