2k9u: Difference between revisions
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{{STRUCTURE_2k9u| PDB=2k9u | SCENE= }} | {{STRUCTURE_2k9u| PDB=2k9u | SCENE= }} | ||
===Solution NMR structure of the Filamin-migfilin complex=== | ===Solution NMR structure of the Filamin-migfilin complex=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/FBLI1_HUMAN FBLI1_HUMAN]] Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.<ref>PMID:12679033</ref><ref>PMID:12496242</ref><ref>PMID:18829455</ref><ref>PMID:19074766</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Filamin|Filamin]] | *[[Filamin|Filamin]] | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Ithychanda, S N.]] | [[Category: Ithychanda, S N.]] | ||
Revision as of 03:22, 25 March 2013
Solution NMR structure of the Filamin-migfilin complexSolution NMR structure of the Filamin-migfilin complex
FunctionFunction
[FBLI1_HUMAN] Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.[1][2][3][4]
About this StructureAbout this Structure
2k9u is a 2 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Tu Y, Wu S, Shi X, Chen K, Wu C. Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell. 2003 Apr 4;113(1):37-47. PMID:12679033
- ↑ Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS. A new member of the LIM protein family binds to filamin B and localizes at stress fibers. J Biol Chem. 2003 Apr 4;278(14):12175-81. Epub 2002 Dec 20. PMID:12496242 doi:10.1074/jbc.M209339200
- ↑ Lad Y, Jiang P, Ruskamo S, Harburger DS, Ylanne J, Campbell ID, Calderwood DA. Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem. 2008 Dec 12;283(50):35154-63. Epub 2008 Sep 30. PMID:18829455 doi:10.1074/jbc.M802592200
- ↑ Ithychanda SS, Das M, Ma YQ, Ding K, Wang X, Gupta S, Wu C, Plow EF, Qin J. Migfilin, a molecular switch in regulation of integrin activation. J Biol Chem. 2009 Feb 13;284(7):4713-22. doi: 10.1074/jbc.M807719200. Epub 2008, Dec 13. PMID:19074766 doi:10.1074/jbc.M807719200