4e96: Difference between revisions
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{{STRUCTURE_4e96| PDB=4e96 | SCENE= }} | {{STRUCTURE_4e96| PDB=4e96 | SCENE= }} | ||
===Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1=== | |||
{{ABSTRACT_PUBMED_23095041}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref><ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
| Line 12: | Line 14: | ||
==See Also== | ==See Also== | ||
*[[Multiple sclerosis|Multiple sclerosis]] | *[[Multiple sclerosis|Multiple sclerosis]] | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
Revision as of 02:56, 25 March 2013
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor PFi-1
Template:ABSTRACT PUBMED 23095041
DiseaseDisease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1][2]
FunctionFunction
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this StructureAbout this Structure
4e96 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Homo sapiens
- Arrowsmith, C H.
- Bunnage, M.
- Cook, A.
- Delft, F von.
- Edwards, A M.
- Fedorov, O.
- Felletar, I.
- Filippakopoulos, P.
- Fish, P.
- Knapp, S.
- Owen, D.
- Picaud, S.
- SGC, Structural Genomics Consortium.
- Weigelt, J.
- Betsoff1
- Bromodomain
- Cap
- Cell cycle
- Hunk1
- Jq1
- Mcap
- Mitotic chromosome associated protein
- Protein binding-inhibitor complex
- Sgc
- Structural genomics consortium