2dl8: Difference between revisions
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{{STRUCTURE_2dl8| PDB=2dl8 | SCENE= }} | {{STRUCTURE_2dl8| PDB=2dl8 | SCENE= }} | ||
===Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2=== | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FNBP2_HUMAN FNBP2_HUMAN]] Note=A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13). | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FNBP2_HUMAN FNBP2_HUMAN]] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.<ref>PMID:20810653</ref><ref>PMID:21148482</ref><ref>PMID:22559944</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2dl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DL8 OCA]. | [[2dl8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DL8 OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Hayashi, F.]] | [[Category: Hayashi, F.]] | ||
Revision as of 02:55, 25 March 2013
Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2Solution structure of the SH3 domain of human SLIT-ROBO Rho GTPase-activating protein 2
DiseaseDisease
[FNBP2_HUMAN] Note=A chromosomal aberration disrupting SRGAP2 has been found in a patient with early infantile epileptic encephalopathy. Balanced translocation t(1;9)(q32;q13).
FunctionFunction
[FNBP2_HUMAN] RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.[1][2][3]
About this StructureAbout this Structure
2dl8 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
ReferenceReference
- ↑ Guo S, Bao S. srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization. J Biol Chem. 2010 Nov 5;285(45):35133-41. doi: 10.1074/jbc.M110.153429. Epub 2010, Sep 1. PMID:20810653 doi:10.1074/jbc.M110.153429
- ↑ Mason FM, Heimsath EG, Higgs HN, Soderling SH. Bi-modal regulation of a formin by srGAP2. J Biol Chem. 2011 Feb 25;286(8):6577-86. doi: 10.1074/jbc.M110.190397. Epub 2010 , Dec 9. PMID:21148482 doi:10.1074/jbc.M110.190397
- ↑ Charrier C, Joshi K, Coutinho-Budd J, Kim JE, Lambert N, de Marchena J, Jin WL, Vanderhaeghen P, Ghosh A, Sassa T, Polleux F. Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. Cell. 2012 May 11;149(4):923-35. doi: 10.1016/j.cell.2012.03.034. Epub 2012 May, 3. PMID:22559944 doi:10.1016/j.cell.2012.03.034
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Homo sapiens
- Hayashi, F.
- Qin, X R.
- RSGI, RIKEN Structural Genomics/Proteomics Initiative.
- Yokoyama, S.
- Formin-binding protein 2
- National project on protein structural and functional analyse
- Nppsfa
- Riken structural genomics/proteomics initiative
- Rsgi
- Sh3 domain
- Signaling protein
- Slit-robo rho gtpase activating protein 2
- Structural genomic