2cse: Difference between revisions
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'''Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution'''<br /> | '''Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution'''<br /> | ||
==Overview== | ==Overview== | ||
Reovirus is a useful model for addressing the molecular basis of membrane | Reovirus is a useful model for addressing the molecular basis of membrane penetration by one of the larger nonenveloped animal viruses. We now report the structure of the reovirus virion at approximately 7.0 A resolution as obtained by electron cryomicroscopy and three-dimensional image reconstruction. Several features of the myristoylated outer capsid protein mu1, not seen in a previous X-ray crystal structure of the mu1-sigma3 heterohexamer, are evident in the virion. These features appear to be important for stabilizing the outer capsid, regulating the conformational changes in mu1 that accompany perforation of target membranes, and contributing directly to membrane penetration during cell entry. | ||
==About this Structure== | ==About this Structure== | ||
2CSE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_2 Mammalian orthoreovirus 2] and [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3 Mammalian orthoreovirus 3]. Full crystallographic information is available from [http:// | 2CSE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_2 Mammalian orthoreovirus 2] and [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3 Mammalian orthoreovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSE OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Mammalian orthoreovirus 3]] | [[Category: Mammalian orthoreovirus 3]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Baker, T | [[Category: Baker, T S.]] | ||
[[Category: Harrison, S | [[Category: Harrison, S C.]] | ||
[[Category: Ji, Y.]] | [[Category: Ji, Y.]] | ||
[[Category: Marinescu, D | [[Category: Marinescu, D C.]] | ||
[[Category: Nibert, M | [[Category: Nibert, M L.]] | ||
[[Category: Zhang, L.]] | [[Category: Zhang, L.]] | ||
[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
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[[Category: reovirus]] | [[Category: reovirus]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:51:55 2008'' | ||
Revision as of 17:51, 21 February 2008
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Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution
OverviewOverview
Reovirus is a useful model for addressing the molecular basis of membrane penetration by one of the larger nonenveloped animal viruses. We now report the structure of the reovirus virion at approximately 7.0 A resolution as obtained by electron cryomicroscopy and three-dimensional image reconstruction. Several features of the myristoylated outer capsid protein mu1, not seen in a previous X-ray crystal structure of the mu1-sigma3 heterohexamer, are evident in the virion. These features appear to be important for stabilizing the outer capsid, regulating the conformational changes in mu1 that accompany perforation of target membranes, and contributing directly to membrane penetration during cell entry.
About this StructureAbout this Structure
2CSE is a Protein complex structure of sequences from Mammalian orthoreovirus 2 and Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.
ReferenceReference
Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution., Zhang X, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert ML, Baker TS, Structure. 2005 Oct;13(10):1545-57. PMID:16216585
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