1dnw: Difference between revisions
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{{STRUCTURE_1dnw| PDB=1dnw | SCENE= }} | {{STRUCTURE_1dnw| PDB=1dnw | SCENE= }} | ||
===HUMAN MYELOPEROXIDASE-CYANIDE-THIOCYANATE COMPLEX=== | |||
{{ABSTRACT_PUBMED_11705390}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[http://omim.org/entry/254600 254600]]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref><ref>PMID:7904599</ref><ref>PMID:8621627</ref><ref>PMID:9637725</ref><ref>PMID:9354683</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN]] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:011705390</ref><references group="xtra"/> | <ref group="xtra">PMID:011705390</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Peroxidase]] | [[Category: Peroxidase]] | ||